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8 products found
$198.00
Catalog number: SBB-PP0086, 50 μg
Highly active protein complex that has been purified from rat red blood cells (RBC). The rat 20S proteasome is able to proteolytically degrade substrates in an ATP-independent manner. The 20S core can be activated chemically with SDS (0.035%) or by the addition of PA28. Initial experiments should be carried out at 20S proteasome concentrations between 2-5 nM.
$198.00
Catalog number: SBB-PP0047, 50 μg
Highly active protein complex that has been purified from mouse red blood cells (RBC). The rat 20S proteasome is able to proteolytically degrade substrates in an ATP-independent manner. The 20S core can be activated chemically with SDS (0.035%) or by the addition of PA28. Initial experiments should be carried out at 20S proteasome concentrations between 2-5 nM.
$189.00
Catalog number: SBB-PP0005, 50 μg
Highly active protein complex that has been purified from human red blood cells (RBC). The Human 20S proteasome is able to proteolytically degrade substrates in an ATP-independent manner. The 20S core can be activated chemically with SDS (0.035%) or by the addition of PA28. Initial experiments should be carried out at 20S proteasome concentrations between 2-5 nM.
Catalog number: SBB-DE0025, 50μg
NEDP1 is a protease which hydrolyzes the isopeptide bond between the C-terminus of NEDD8 and the respective lysine of the substrate protein to which the NEDD8 is covalently bound. This NEDP1 is his-tagged on the N-terminus, recombinantly expressed in E. coli.
Catalog number: SBB-DE0024, 50 μg
The severe acute respiratory syndrome coronavirus papain-like protease (SARS-CoV His6-PLpro) is involved in the processing of the viral polyprotein. Proteolytic processing of the coronavirus replicase poly-protein is essential for generating a functional virus replication complex. PLpro is able to hydrolyze both ISG15-Rhodamine110 or diubiquitin/tetra-ubiquitin substrates, but is very inefficient when processing mono-Ub conjugates or synthetic peptide substrates. This PLpro is N-terminally His6 tagged and expressed in E.coli.
$189.00
Catalog number: SBB-DE0023, 50 μg
UCHL3 is a deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. It is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. It digests precursors and ubiquitinated proteins to generate monomeric ubiquitin. This UCHL3 is recombinatly expressed in E.coli.
$189.00
Catalog No. SBB-DE0127, 50 gThe severe acute respiratory syndrome coronavirus papain-like protease (SARS-CoV-2 PLpro) is involved in the processing of the viral polyprotein. Proteolytic processing of the coronavirus replicase poly-protein is essential for generating a functional virus replication complex. PLpro possesses both deubiquitinating or deISGylating activity and can process Lys- 48 and Lys-63 linked polyubiquitin chains (free chains or from cellular substrates).
Catalog number: SBB-UP0013,10 mgUbiquitin, human recombinant, is a small (8.
5 kDa) regulatory protein that has been found in almost all tissues of eukaryotic organisms. The addition of ubiquitin to a substrate protein is called ubiquitination or ubiquitylation. Ubiquitination can affect proteins in many ways: it can signal for their degradation via the proteasome, alter their cellular location, affect their activity, and promote or prevent protein interactions. [1][2][3][4][5]
