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Catalog number: SBB-SC0140, 25 μg
The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the DCX E3 ubiquitin-protein ligase complex is determined by the variable substrate recognition component recruited by DDB1. The protein has an N-terminal 8x-His Tag followed by an Avi-Tag that was endogenous biotinylated during expression in Sf21 Cells.
$295.00
Catalog number: SBB-SC0140, 25 µg
DDB1 - DNA damage-binding protein 1, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively. Core component of the UV-DDB complex (UV-damaged DNA-binding protein complex), a complex that recognizes UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair.
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$295.00
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| Quantity: | 50 μg |
|---|---|
| Molecular Weight: | 130 kDa |
| Purity: | >98% by SDS-PAGE |
| Storage Buffer: | 25 mM HEPES, pH 7.5, 150 mM NaCl, 0.1 mM TCEP (no detergents or glycerol) |
| Storage | Store at −80°C after product arrival. Avoid multiple freeze / thaws. |
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